When medical cannabis became legal in California in 1996, it was the first state to legalize it. This occasion was a major turning point in the history of CBD, and it was probably its most defining moment. At that time, the rest of the country was slower to adopt the progressive thoughts on the cannabis sativa plant. But the newly legalized status of the cannabis plant demonstrated that it was on its way to becoming more mainstreamed. Research on CBD became both more abundant and more informative.
Research on the potential benefits of CBD began to increase gradually throughout the early 2000 years. By 2002, scientists became confident that they had gathered enough information to believe that they could draw some conclusions about how CBD affects the body. In reviewing the available evidence, the researchers confirmed that CBD did not appear to affect any of the cannabinoid receptors. It did seem to possess many therapeutic properties, such as anti-anxiety, anti convulsive, anti nausea, anti psychotic and anti rheumatoid arthritic qualities. These conclusions were drawn from the available and current research at that time.
Since that time period in establishing that CBD showed potential for various conditions, CBD has been found not to be toxic in non-transformed cells, and does not cause changes in food intake, not does it affect physiological parameters such as blood pressure, heart rate or body temperature. Chronic use at dosages of up to 1,500 mg of CBD have been reported as being well tolerated in humans. It can induce some side effects physiologically, such as decreased fertility capability and decreases in some proteins and other drug transporters. Controlled usage of CBD is thought to be safe in both animals and humans, based on recent advances in cannabinoids. As has been often concluded, further studies are needed to clarify the effects of CBD, both in vitro and in vivo.