- This topic has 0 replies, 1 voice, and was last updated 3 years, 3 months ago by
.
-
Posts
-
In the post regarding the neurotransmitters with which CBD interacts to help to alleviate anxiety, I would like to add the brain chemical, anandamide. This substance is part of the endogenous cannabinoid system, ECS, and is another potential channel through which CBD produces anti-anxiety, or anxiolytic, effects. CBD has been shown to increase cannabinoid receptor activity in an indirect manner, by increasing levels of the endocannabinoid through the metabolism of anandamide. The CBD actually inhibits a fatty acid, amide hydrolase enzyme, from metabolizing anandamide, so that its levels are increased and CB1 activation is also indirectly enhanced.
These activities in the brain can help to produce an overall calming effect for anxiety. Also, this CB1 receptor activity has been thought to regulate fear processing, by balancing CBD levels. This mechanism is called endocannabinoid signaling, and is part of a complex, overall system known as the endogenous anxiolytic neuromodulary system. The inhibition of the fatty acid amide hydrolase enzyme, FAAH, shows promise as a therapeutic approach to reducing anxiety and its related symptoms.
- You must be logged in to reply to this topic.